Tesamorelin

Tesamorelin

Price range: $100.00 through $150.00

Tesamorelin is a research peptide that acts as a synthetic version of growth hormone-releasing hormone (GHRH), designed to naturally boost the body’s own growth hormone production. Studies have explored its potential to reduce visceral fat, improve metabolic health, and support cognitive function. This lyophilized powder requires reconstitution before use and is intended exclusively for laboratory research purposes-not for human or animal consumption.

Research has shown promise in addressing stubborn abdominal fat while potentially enhancing insulin sensitivity and supporting brain health. Tesamorelin represents an innovative approach to metabolic research, offering scientists a tool to study how targeted growth hormone stimulation might address various age-related and metabolic concerns. This product is exclusively for laboratory research and not for human or animal use.

Overview

Think of Tesamorelin as a sophisticated messenger that knocks on your pituitary gland’s door and politely asks it to produce more growth hormone. Unlike synthetic growth hormone that floods the system all at once, Tesamorelin works more like a dimmer switch than an on/off button-it encourages your body to release growth hormone in a more natural, pulsatile pattern. This research peptide has attracted significant scientific interest for its ability to target visceral fat (the stubborn fat around internal organs) while potentially supporting brain function and metabolic health.

Important: This product is exclusively for laboratory research and not for human or animal use. Researchers must follow proper handling protocols and safety guidelines.

This product is strictly for research purposes only. Not approved for human or animal use.

Key Characteristics

MOLECULAR PROFILE

Formula: C221H366N72O67S

Weight: 5135.9 g/mol

CAS: 218949-48-5

Alternative Names: TH9507, Egrifta

PHYSICAL PROPERTIES

Form: Lyophilized white to off-white powder

Solubility: Water-soluble

Storage: Requires refrigeration after reconstitution

Structure: 44 amino acid peptide

How It Works

Tesamorelin operates by mimicking the body’s natural growth hormone-releasing hormone. When introduced in research settings, it binds to specific receptors (GHRHR) in the pituitary gland-imagine it as having the exact key to unlock growth hormone production.

Primary Mechanisms

GHRHR Receptor Binding

Binds to growth hormone-releasing hormone receptors in the pituitary

Growth Hormone Release

Triggers cascade resulting in increased GH secretion

IGF-1 Stimulation

Promotes production of insulin-like growth factor-1 in the liver

Physiological Effects

Pulsatile Release Pattern

Works with body’s natural rhythms for physiological response

Selective Action

Targeted approach avoiding constant hormone flooding

Metabolic Regulation

Influences fat metabolism and insulin sensitivity

Research Findings

Scientific studies have revealed Tesamorelin’s multi-faceted effects on metabolism, body composition, and cognitive function.

Visceral Fat Reduction

Multiple studies have demonstrated Tesamorelin’s remarkable ability to target dangerous abdominal fat:

15-20% reduction in visceral adipose tissue over 6 months
Selective targeting of fat around internal organs
Valuable tool for metabolic syndrome research
Maintained effects with continued administration

Metabolic Health Improvements

Scientists have observed significant metabolic benefits in research subjects:

Enhanced insulin sensitivity markers
Improved glucose metabolism
Better cellular response to insulin
Potential applications in diabetes research

Cognitive Function Support

Emerging research indicates neuroprotective properties and brain health benefits:

Improvements in mild cognitive impairment subjects
Enhanced executive function performance
Potential role in maintaining neuroplasticity
Growth hormone’s influence on brain health

Body Composition Changes

Research has documented comprehensive improvements in physical parameters:

Increased lean muscle mass retention
Enhanced strength and performance metrics
Relevant for aging and sarcopenia research
Improved overall body composition ratios

Bone Health Potential

Preliminary data suggests benefits for skeletal health through hormonal pathways:

Support for bone density maintenance
Effects mediated through GH and IGF-1
Interest in osteoporosis research applications
Further studies needed for confirmation

Potential Side Effects in Research

During clinical research, scientists have documented several potential side effects that must be considered:

Injection Site Reactions

Redness, swelling, or irritation at administration sites

Fluid Retention

Edema, particularly in extremities, observed in some subjects

Joint Discomfort

Reports of arthralgia or joint pain in research settings

Hypersensitivity

Rare allergic reactions documented in clinical studies

Neurological Effects

Headaches and dizziness in some research participants

Gastrointestinal

Digestive disturbances reported in experimental models

Researchers must carefully monitor for these effects and maintain detailed documentation throughout their studies.

IMPORTANT: This product is exclusively for laboratory research purposes and is not approved for human or veterinary use.

References

  1. Makimura H, et al. “Tesamorelin reduces visceral adipose tissue and liver fat in INSTI-treated persons with HIV.” Open Forum Infect Dis. 2023.
  2. Stanley TL, et al. “Effects of tesamorelin on inflammatory markers in HIV patients with excess abdominal fat.” AIDS. 2013.
  3. Samaras K, et al. “Effect of tesamorelin in people with HIV with and without dorsocervical fat: Post hoc analysis of phase III trial.” HIV Med. 2023.
  4. Makimura H, et al. “Metabolic effects of a growth hormone-releasing factor in visceral adiposity.” J Clin Endocrinol Metab. 2018.
  5. Vilar L, et al. “Growth hormone-releasing hormone analogs and cognitive function.” Pituitary. 2017.
  6. Clemmons DR. “The relative roles of growth hormone and IGF-1 in metabolic regulation.” Growth Horm IGF Res. 2019.
  7. Friedman SD, Baker LD, et al. “Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment.” JAMA Neurol. 2013.
  8. Stanley TL, Grinspoon SK. “Growth hormone-releasing hormone in HIV-associated lipodystrophy: Current evidence and future directions.” Front Endocrinol. 2024.
  9. Fourman LT, et al. “Effects of tesamorelin on hepatic transcriptomic signatures.” JCI Insight. 2020.

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