NAD+

NAD+

$95.00

NAD+ is the cellular powerhouse coenzyme that fuels life itself. Found in every living cell, this essential molecule plays a starring role in energy production, DNA repair, and cellular communication. As we age, NAD+ levels naturally decline, making it a fascinating target for longevity research. This pure form offers researchers a direct way to study metabolic processes, aging mechanisms, and cellular health. Each vial contains pure, lyophilized powder for reconstitution.

This product is exclusively for laboratory research and not for human or animal use. This product is exclusively for laboratory research and not for human or animal use.

Overview

Nicotinamide Adenine Dinucleotide (NAD+) is arguably the most important molecule you’ve never heard of. Present in every cell of every living organism, NAD+ is like the currency of cellular energy – without it, life as we know it would cease to exist. This coenzyme doesn’t just participate in energy production; it’s a critical player in DNA repair, gene expression, immune function, and the aging process itself. The discovery that NAD+ levels decline with age has sparked intense research interest in its potential for extending healthspan and lifespan.

This product is strictly for research purposes only. Not approved for human or animal use.

Key Characteristics

MOLECULAR PROFILE

Formula: C21H27N7O14P2

Weight: 663.43 g/mol

CAS: 53-84-9

Structure: Dinucleotide

PHYSICAL PROPERTIES

Form: White lyophilized powder

Solubility: Highly water-soluble

Stability: Light and heat sensitive

Storage: Keep refrigerated 36‑46 °F (2‑8 °C), protect from light

How It Works

NAD+ operates as a master regulator of cellular function through multiple mechanisms:

Primary Functions

Redox Reactions

Shuttles electrons in over 400 enzymatic reactions throughout the cell.

Sirtuin Activation

Fuels sirtuins, the “longevity proteins” that regulate aging processes.

PARP Activation

Powers DNA repair enzymes called PARPs for genomic stability.

Metabolic Pathways

Energy Metabolism

Essential for converting nutrients into ATP through glycolysis and the citric acid cycle.

Fatty Acid Oxidation

Critical for fat metabolism and oxidative phosphorylation.

Calcium Signaling

CD38 substrate involved in calcium signaling and immune function.

Research Findings

The research on NAD+ has revealed its profound impact on health and aging across multiple biological systems.

Longevity and Aging

Studies demonstrate remarkable anti-aging effects across multiple species.

Extended lifespan in yeast, worms, and mice models
Restoration of youthful cellular function
Improved mitochondrial health with age
Enhanced DNA repair capacity
Reduced cellular senescence
Protection against age-related diseases

Metabolic Health

Research shows significant metabolic improvements and protection.

Enhanced insulin sensitivity
Improved glucose metabolism
Better lipid profiles
Increased metabolic flexibility
Protection against metabolic syndrome
Reduced inflammation markers

Cardiovascular Benefits

Studies reveal heart and vascular protection mechanisms.

Improved cardiac function
Enhanced blood vessel elasticity
Protection against heart failure
Reduced atherosclerosis
Better blood pressure regulation
Improved endothelial function

Neuroprotection

Research indicates significant brain health benefits.

Protection against neurodegeneration
Improved cognitive function
Enhanced memory and learning
Reduced risk of Alzheimer’s pathology
Better neuronal energy metabolism
Protection against stroke damage

DNA Repair and Cancer Prevention

Studies show genomic stability and protective effects.

Enhanced DNA damage repair
Reduced mutation accumulation
Protection against UV damage
Improved chromosomal stability
Potential cancer prevention properties

Immune Function

Research reveals immune system optimization benefits.

Enhanced T-cell function
Better inflammatory regulation
Improved response to infections
Reduced chronic inflammation
Better immune surveillance

Exercise Performance

Studies indicate physical performance improvements.

Enhanced mitochondrial biogenesis
Improved muscle function
Better exercise capacity
Faster recovery times
Increased endurance

Potential Side Effects in Research

NAD+ generally shows excellent tolerability in research settings:

Flushing

Temporary skin flushing at high doses

Itching

Mild pruritis in some subjects

Gastrointestinal

Occasional mild GI discomfort

Headache

Rare reports of mild headaches

Liver Concerns

Very high doses may affect liver enzymes

Generally Safe

Well-tolerated at physiological doses

Overall safety profile appears favorable across multiple research studies and model systems.

IMPORTANT: This product is exclusively for laboratory research purposes and is not approved for human or veterinary use.

References

  1. Reiten OK, et al. “Therapeutic targeting of NAD+ metabolism in mitochondrial disease.” Cell. 2023.
  2. Covarrubias AJ, et al. “NAD+ metabolism and its roles in cellular processes during ageing.” Nat Rev Mol Cell Biol. 2021.
  3. Abdellatif M, et al. “NAD+ metabolism and cardiovascular diseases.” Nature Cardiovascular Research. 2024.
  4. Sharma A, et al. “NAD+ boosting reverses vascular aging in mice.” Nature Aging. 2023.
  5. Li C, et al. “NAD+ enhances mitochondrial function and longevity pathways.” Science. 2024.
  6. Dall M, et al. “NAD+ and metabolic regulation of age-related proteostasis.” Nature Metabolism. 2023.
  7. Lautrup S, et al. “NAD+ in Brain Aging and Neurodegenerative Disorders.” Cell Metab. 2019.
  8. Reiten OK, et al. “Preclinical and clinical evidence of NAD+ precursors.” Nat Aging. 2021.
  9. Kane AE, Sinclair DA. “Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases.” Circ Res. 2018.
  10. Navas LE, Carnero A. “NAD+ metabolism, stemness, the immune response, and cancer.” Signal Transduct Target Ther. 2021.

Third-Party Lab Tested

View our independent laboratory test certificate showing purity and composition analysis.


📋 View Test Certificate →

Weight 1 lbs
Dimensions N/A
Size

500mg
Lab Tested and Shipped from the USA
Free Bacteriostatic Water
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