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Melanotan 2

Melanotan 2

Price range: $35.00 through $55.00

Melanotan 2 (MT-2) is a synthetic peptide that mimics your body’s natural tanning hormone. Research suggests MT-2 can stimulate melanin production without sun exposure. Studies also show promising effects on sexual function and appetite regulation. Scientists continue exploring its influence on reward pathways and metabolic processes. Each vial contains pure, lyophilized powder ready for reconstitution.

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Overview

Melanotan 2 represents a revolutionary advancement in melanocortin receptor research. This cyclic heptapeptide analog of α-MSH features a unique lactam bridge structure that enables broad receptor activation across MC1R, MC3R, MC4R, and MC5R. Unlike its linear predecessor Melanotan 1, MT-2’s compact cyclic architecture provides enhanced stability and multi-system biological activity. Originally developed for pigmentation research, MT-2 has emerged as a valuable tool for investigating diverse physiological processes including sexual function, appetite regulation, and energy homeostasis. Its non-selective receptor profile makes it particularly valuable for studying the interconnected nature of melanocortin signaling pathways.

This product is strictly for research purposes only. Not approved for human or animal use.

Key Characteristics

MOLECULAR PROFILE

Formula: C50H69N15O9

Weight: 1024.20 g/mol

CAS: 121062-08-6

Structure: Cyclic heptapeptide with lactam bridge

PHYSICAL PROPERTIES

Form: White to off-white lyophilized powder

Solubility: Soluble in water and acetic acid

Selectivity: Non-selective MC1R/3R/4R/5R agonist

Storage: Keep refrigerated 36‑46 °F (2‑8 °C)

How It Works

MT-2’s multi-receptor activation creates diverse biological effects:

Primary Mechanisms

Multi-Receptor Binding

Activates MC1R, MC3R, MC4R, and MC5R simultaneously

G-Protein Coupling

Triggers Gs-mediated cAMP accumulation across cell types

PKA Activation

Phosphorylates CREB and other transcription factors

Cyclic Structure

Lactam bridge provides enhanced stability and bioavailability

System-Specific Effects

Melanogenesis (MC1R)

Stimulates eumelanin production in melanocytes

Sexual Function (MC4R)

Modulates arousal pathways in the CNS

Energy Balance (MC3R/4R)

Influences appetite and metabolic regulation

Research Findings

MT-2’s broad receptor profile has revealed diverse research applications:

Enhanced Melanogenesis

Superpotent pigmentation effects:

10-fold greater potency than natural α-MSH
Rapid onset of pigmentation without UV exposure
Sustained melanin production after discontinuation
Darkening of melanocytic nevi observed

Sexual Response Studies

MC4R-mediated effects documented:

Spontaneous erectile responses in male subjects
Increased arousal in both sexes via CNS pathways
Led to development of bremelanotide (PT-141)
Activation of hypothalamic circuits

Metabolic Regulation

Energy homeostasis effects:

Reduced appetite through MC4R activation
Altered fat metabolism in animal models
Influence on insulin sensitivity markers
Thermogenic effects observed

Behavioral Modulation

CNS effects beyond sexual function:

Reduced addictive behaviors in models
Altered reward pathway signaling
Potential dopaminergic interactions
Effects on social behavior patterns

Potential Side Effects in Research

MT-2’s multi-receptor activity produces diverse physiological responses:

Nausea and Reduced Appetite

Common gastrointestinal effects via MC4R

Facial Flushing

Vasodilation and increased blood flow

Spontaneous Erections

MC4R activation in male subjects

Stretching and Yawning

Central melanocortin system activation

MT-2’s non-selective receptor profile produces more systemic effects compared to selective melanocortin agonists.

IMPORTANT: This product is exclusively for laboratory research purposes and is not approved for human or veterinary use.

References

  1. Maurya MR, Munshi R, Zambare S. Melanocortin Receptors: Emerging Targets for the Treatment of Pigmentation, Inflammation, Stress, Weight Disorders and Sexual Dysfunction. Curr Drug Targets. 2023;24(2):151-156.
  2. Li H, Xu Y, Jiang Y, et al. The melanocortin action is biased toward protection from weight loss in mice. Nat Commun. 2023;14:2200.
  3. Goit RK, Taylor AW, Lo ACY. The central melanocortin system as a treatment target for obesity and diabetes: A brief overview. Eur J Pharmacol. 2022;924:174956.
  4. De Jonghe BC, Hayes MR, Bence KK. Melanocortin control of energy balance: evidence from rodent models. Cell Mol Life Sci. 2011;68(15):2569-2588.
  5. Edinoff AN, Sanders NM, Lewis KB, et al. Bremelanotide for Treatment of Female Hypoactive Sexual Desire. Neurol Int. 2022;14(1):75-88.
  6. Dorr RT, Lines R, Levine N, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci. 1996;58(20):1777-1784.
✓ THIRD-PARTY LAB TESTED

Certificate of Analysis

Independent laboratory testing confirms purity and composition

99.735%
Purity
56ABF
Batch
December 2025
Date
View Certificate →
Weight 0.08 lbs
Dimensions 0.87 × 1.18 × 0.87 in
Size

5mg, 10mg
SKU: OATH-MELANOTAN-2 Category: Tags: , , , , , , , ,
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