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Melanotan 1

Melanotan 1

$55.00

Melanotan 1 (MT-1) is a synthetic peptide being studied for its remarkable skin-protective properties. Research suggests it may help activate natural tanning responses, offering potential protection against sun damage. Studies show MT-1 may also support skin health in conditions where light sensitivity is a concern. Scientists are exploring its possible anti-inflammatory benefits and tissue-protective effects.

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Overview

Melanotan 1 represents a targeted approach to melanocortin receptor activation. Unlike its cyclic cousin Melanotan 2, MT-1 maintains a linear structure that provides selective MC1R activation, making it ideal for research focused on melanogenesis and photoprotection without unwanted side effects. This selectivity has made MT-1 particularly valuable in dermatological research, where it serves as a model compound for understanding UV protection mechanisms and melanin biology. Beyond skin pigmentation, emerging research reveals MT-1’s anti-inflammatory properties and potential neuroprotective effects.

This product is strictly for research purposes only. Not approved for human or animal use.

Key Characteristics

MOLECULAR PROFILE

Formula: C78H111N21O19

Weight: 1646.85 g/mol

CAS: 75921-69-6

Structure: Linear 13-amino acid peptide

PHYSICAL PROPERTIES

Form: White to off-white lyophilized powder

Solubility: Readily dissolves in water

Selectivity: High MC1R selectivity

Storage: Keep refrigerated 36‑46 °F (2‑8 °C)

How It Works

MT-1’s selective mechanism provides targeted biological effects:

Primary Mechanisms

MC1R Activation

Selectively binds to melanocortin-1 receptors on melanocytes

cAMP Signaling

Increases intracellular cAMP, activating protein kinase A

MITF Activation

Upregulates microphthalmia-associated transcription factor

Melanogenesis

Stimulates tyrosinase and other melanogenic enzymes

Protective Mechanisms

UV Protection

Enhanced melanin production provides natural photoprotection

DNA Repair

May enhance nucleotide excision repair mechanisms

Anti-inflammatory

Reduces inflammatory cytokine production

Research Findings

MT-1 research has revealed diverse applications beyond pigmentation:

Photoprotection Studies

Primary research focus on UV protection:

Increased melanin density without UV exposure
Reduced UV-induced DNA damage markers
Protection in photosensitivity disorder models
Sustained protective effects after discontinuation

Anti-inflammatory Effects

Emerging immunomodulatory properties:

Reduced TNF-α and IL-1β production
Suppression of NF-κB activation
Protection in inflammatory disease models
Potential in autoimmune research

Neuroprotective Research

Unexpected central nervous system effects:

Protection against oxidative stress in neurons
Reduced neuroinflammation markers
Potential in neurodegenerative disease models
Improved outcomes in stroke models

Clinical Research Applications

Translational research findings:

Erythropoietic protoporphyria studies
Polymorphous light eruption research
Vitiligo repigmentation investigations
Solar urticaria protection studies

Potential Side Effects in Research

MT-1 demonstrates a favorable safety profile with selective receptor targeting:

Mild Nausea

Transient gastrointestinal effects in some subjects

Facial Flushing

Temporary vasodilation effects

Fatigue

Mild tiredness reported in some studies

Pigmentation Changes

Expected darkening of skin and melanocytic nevi

MT-1’s MC1R selectivity minimizes off-target effects seen with broader melanocortin agonists.

IMPORTANT: This product is exclusively for laboratory research purposes and is not approved for human or veterinary use.

References

  1. Polańska A. Afamelanotide in protoporphyria and other skin diseases: comprehensive review. Skin Health Dis. 2024;4(2):e102-e110.
  2. Resnik SR, Targett D, Resnik BI. Into the light: afamelanotide and the treatment of erythropoietic protoporphyria in the United States. J Drugs Dermatol. 2023;22(9):941-949.
  3. Leaf RK, et al. Afamelanotide for treatment of the protoporphyrias: impact on quality of life and laboratory parameters in a US cohort. Life (Basel). 2024;14(6):689.
  4. Wensink D, Wagenmakers M, Langendonk JG. Afamelanotide for prevention of phototoxicity in erythropoietic protoporphyria. Expert Rev Clin Pharmacol. 2021;14(2):151-160.
  5. Langendonk JG, et al. Afamelanotide for erythropoietic protoporphyria. N Engl J Med. 2015;372(20):1909-1917.
  6. Böhm M, Bodó E, Funk W, Paus R. α-Melanocyte-stimulating hormone: a protective peptide against chemotherapy-induced hair follicle damage? Br J Dermatol. 2014;170(4):956-960.
✓ THIRD-PARTY LAB TESTED

Certificate of Analysis

Independent laboratory testing confirms purity and composition

99.865%
Purity
10HBE
Batch
August 2025
Date
View Certificate →
Weight 0.08 lbs
Dimensions 0.87 × 1.18 × 0.87 in
Size

5mg, 10mg
SKU: OATH-MELANOTAN-1 Category: Tags: ,
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