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KPV

KPV

$65.00

Research shows KPV may help calm inflammation throughout the body. This small but mighty tripeptide comes from a natural hormone and has caught researchers’ attention for its potential to support gut health, promote skin healing, and reduce inflammatory responses. Studies suggest it works by blocking pathways that trigger inflammation at the cellular level. Scientists are exploring its use for digestive issues and skin conditions alike.

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Overview

Imagine your body’s inflammatory response as a fire alarm system. Sometimes this alarm gets stuck in the “on” position, causing unnecessary inflammation even when there’s no real threat. KPV works like a specialized technician that can help reset this alarm system, potentially turning down the volume on excessive inflammatory signals.

KPV is a synthetic tripeptide-essentially a chain of three amino acids (lysine, proline, and valine) linked together. This small but mighty molecule is derived from alpha-melanocyte-stimulating hormone (α-MSH), a naturally occurring compound in the body known for its anti-inflammatory properties. What makes KPV special is that it represents the smallest active fragment of α-MSH that still retains powerful anti-inflammatory capabilities, making it an efficient subject for research studies.

This product is strictly for research purposes only. Not approved for human or animal use.

Key Characteristics

MOLECULAR PROFILE

Formula: C16H29N3O4

Weight: 327.42 g/mol

CAS: 67727-97-3

Structure: Lysine-Proline-Valine

PHYSICAL PROPERTIES

Form: White to off-white lyophilized powder

Solubility: Water-soluble (≥1 mg/mL)

Reconstitution: Required with bacteriostatic water

Storage: Store in a cool, dry place away from light

How It Works

KPV operates through a fascinating mechanism that researchers are still working to fully understand. Think of inflammation as a complex orchestra where different instruments (inflammatory molecules) can sometimes play too loudly or out of tune. KPV acts like a conductor, helping to restore harmony by modulating how these inflammatory signals are expressed.

Primary Mechanisms

Regulating Cytokines

These are the body’s chemical messengers that control inflammation. KPV may help dial down pro-inflammatory cytokines while potentially supporting anti-inflammatory ones.

Modulating Immune Cells

Research suggests KPV can influence how immune cells like macrophages and T cells behave, potentially shifting them from an inflammatory state to a more balanced one.

Cellular Actions

Activating Melanocortin Receptors

These specialized receptors are like cellular switches that, when activated, can trigger anti-inflammatory responses throughout the body.

Research Findings

Laboratory investigations have revealed multiple areas where KPV demonstrates interesting research potential.

Digestive System Studies

Laboratory investigations have shown intriguing results regarding KPV’s effects on digestive health models.

May help maintain the integrity of the gut lining
Modulates inflammatory responses in digestive tissue samples
Interest in applications for inflammatory bowel conditions

Joint and Connective Tissue Research

Studies examining KPV’s effects on joint tissues have yielded promising preliminary data.

May regulate inflammatory processes in connective tissues
Subject of interest for arthritis research
Potential applications in joint health studies

Skin and Wound Healing Investigations

Laboratory experiments have explored KPV’s role in skin health and repair processes.

May support natural healing mechanisms
Helps maintain skin barrier function in research models
Early findings show promise for tissue repair studies

Neurological Research Applications

Emerging studies are investigating KPV’s potential effects on neuroinflammation.

Early-stage research on neuroinflammatory processes
Potential applications in nervous system models
May influence inflammatory responses in neural tissue

Cellular Regeneration Studies

Research has indicated that KPV may play a role in supporting cellular repair processes.

Influences cellular response to damage
May initiate repair mechanisms
Supports regeneration processes in laboratory models

Potential Side Effects in Research

While preclinical studies in laboratory models have generally shown KPV to be well-tolerated, researchers should be aware of the following considerations:

Safety Data

Limited long-term safety data is available, as most studies have focused on short-term applications

Variable Responses

Individual cellular responses may vary in different research models

Compound Interactions

Potential interactions with other compounds in experimental settings remain under investigation

Dosing Parameters

Optimal dosing parameters for various research applications are still being established

Researchers should maintain careful documentation of all observations during experiments and follow appropriate safety protocols when handling this research compound.

IMPORTANT: This product is exclusively for laboratory research purposes and is not approved for human or veterinary use.

References

  1. Dalmasso G, et al. “PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.” Gastroenterology. 2008.
  2. Kannengiesser K, et al. (2008). Melanocortin-derived tripeptide KPV has anti-inflammatory potential.
  3. Brzoska T, et al. (2008). α-MSH and related peptides: from bench to bedside.
  4. Ma C, et al. “Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of KPV.” Cell Mol Gastroenterol Hepatol. 2016.
  5. Zhao Y, et al. “KPV-binding double-network hydrogel restores gut mucosal barrier in colitis.” Acta Biomater. 2022.
  6. Zhao J, et al. “The melanocortin system in inflammatory bowel diseases: insights and therapeutic potentials.” Cells. 2023.
  7. Li M, et al. “PepT1-targeted nanodrug co-assembly for combined treatment of colitis.” Front Pharmacol. 2024.
  8. Manna SK & Aggarwal BB. (1998). α-Melanocyte-stimulating hormone inhibits inflammatory response.
  9. Raap U, et al. (2003). Modulation of neurogenic inflammation by α-MSH.
✓ THIRD-PARTY LAB TESTED

Certificate of Analysis

Independent laboratory testing confirms purity and composition

99.391%
Purity
41HBE
Batch
August 2025
Date
View Certificate →
Weight 0.08 lbs
Dimensions 0.87 × 1.18 × 0.87 in
Size

10mg
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