Price range: $48.00 through $68.00
Kisspeptin-10 is a master regulator of reproductive function and fertility, acting as a potent stimulator of the hypothalamic-pituitary-gonadal axis. Research demonstrates it rapidly increases LH and sex hormone release through KISS1R receptor activation on GnRH neurons.
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Kisspeptin-10 is a potent neuroendocrine peptide representing the minimal active fragment of the KISS1 gene product. Research demonstrates it serves as the master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Despite being the smallest bioactive kisspeptin fragment, studies show it retains full biological activity comparable to kisspeptin-54, binding KISS1R with high affinity (Ki = 0.042 nM).
This product is strictly for research purposes only. Not approved for human or animal use.
Formula: C₆₃H₈₃N₁₇O₁₄
Weight: 1302.45 g/mol
CAS: 374675-21-5
Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH₂
Form: White lyophilized powder
Purity: ≥98% (HPLC)
Solubility: Highly soluble in bacteriostatic water
Storage: Keep refrigerated 36‑46 °F (2‑8 °C)
Binds KISS1R on hypothalamic GnRH neurons, initiating G protein-coupled signaling cascades.
Activates phospholipase C, generating second messengers that trigger calcium release and PKC activation.
Produces rapid, dose-dependent LH increases with subsequent sex hormone elevation.
Potentiates glucose-stimulated insulin secretion; protects blood-brain barrier integrity.
Reproductive Hormone RegulationIntravenous kisspeptin-10 produces rapid, dose-dependent LH elevation in healthy men
Intranasal kisspeptin-54 stimulates gonadotropin release without adverse events (Mills et al., 2025)
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Sexual FunctionIn men with HSDD, kisspeptin increased penile tumescence by 56% vs placebo (Mills et al., 2023)
In women with HSDD, increased ratings of “feeling sexy” (P=0.04)
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Metabolic EffectsEnhances insulin secretion in response to glucose loading
Kiss1r knockout mice display higher body weight and impaired glucose tolerance (Tolson et al., 2014)
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NeuroprotectionIn stroke models, reduced infarct volume and BBB permeability (Li et al., 2025)
Exhibits antioxidant effects via Nrf2 pathway activation
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Cancer ResearchReduced cell viability and migration in triple-negative breast cancer cells
Low kisspeptin correlates with aggressive endometrial cancer stages (Wu et al., 2024)
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Fertility ResearchKisspeptin-54 achieved oocyte fertilization in 93.7% of IVF patients and embryo transfer in 91.4%
May reduce ovarian hyperstimulation syndrome risk vs hCG
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In randomized trials, kisspeptin was well tolerated with no serious adverse events. Most common effects include mild injection site reactions and transient facial flushing. Extensive monitoring shows no significant effects on blood pressure or heart rate. A 2024 systematic review of 29 trials concluded kisspeptin has considerably fewer side effects due to simulating normal physiological processes.
IMPORTANT: This product is exclusively for laboratory research purposes and is not approved for human or veterinary use.
| Weight | 0.08 lbs |
|---|---|
| Dimensions | 0.87 × 1.18 × 0.87 in |
| Size | 5mg, 10mg |
