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Ipamorelin

Ipamorelin

Price range: $55.00 through $95.00

Research suggests ipamorelin is one of the most selective growth hormone secretagogues available. This pentapeptide stimulates growth hormone release without triggering unwanted cortisol or stress hormones. Studies show it may increase growth hormone levels up to 13-fold above baseline while supporting lean muscle, fat reduction, and bone density. Unlike other peptides, ipamorelin offers precision targeting with minimal side effects, making it a popular choice for body composition and recovery research.

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Overview

Ipamorelin represents the gold standard in growth hormone secretagogue research. What sets this peptide apart is its remarkable selectivity – it’s like a precision key that fits only one lock. While other growth hormone releasing compounds often trigger a cascade of hormonal changes, Ipamorelin focuses solely on growth hormone release, making it an invaluable tool for researchers who need clean, predictable results without confounding variables.

This product is strictly for research purposes only. It is not approved for human or animal use and should only be handled by qualified researchers in appropriate laboratory settings.

Key Characteristics

MOLECULAR PROFILE

Formula: C38H49N9O5

Weight: 711.86 g/mol

CAS: 170851-70-4

Structure: Aib-His-D-2-Nal-D-Phe-Lys

PHYSICAL PROPERTIES

Form: White to off-white lyophilized powder

Solubility: Readily dissolves in water

Selectivity: Highly selective for GH release

Storage: Keep refrigerated 36‑46 °F (2‑8 °C)

How It Works

Ipamorelin’s mechanism is elegantly simple yet highly effective:

Primary Mechanism

Ghrelin Receptor Activation

Selectively binds to GHS-R1a receptors on the pituitary gland

Targeted GH Release

Stimulates growth hormone secretion without affecting ACTH, cortisol, or prolactin

Pulsatile Pattern

Mimics the body’s natural GH release patterns

No Desensitization

Maintains effectiveness even with repeated use in research

What Makes It Unique

Unlike other GH secretagogues that can be like using a sledgehammer, Ipamorelin is more like a surgical scalpel. It precisely targets growth hormone release without the hormonal “noise” that can complicate research results. This selectivity makes it ideal for studies where researchers need to isolate the effects of growth hormone alone.

Research Findings

Extensive research has revealed Ipamorelin’s diverse potential:

Growth Hormone Secretion

Studies consistently demonstrate:

Dose-dependent increases in GH levels
Preservation of natural pulsatile GH patterns
No significant increase in cortisol or prolactin
Sustained effectiveness without tachyphylaxis
Similar GH release magnitude to GHRH

Body Composition Effects

Research shows improvements in:

Lean muscle mass preservation
Fat metabolism enhancement
Improved nitrogen retention
Better protein synthesis
Reduced visceral adiposity

Bone Health Support

Studies indicate benefits for skeletal health:

Increased bone mineral density
Enhanced bone formation markers
Improved calcium retention
Better trabecular bone structure
Potential for osteoporosis research

Cardiovascular Function

Research reveals cardiovascular benefits:

Improved cardiac output
Better endothelial function
Enhanced recovery from cardiac stress
Potential cardioprotective effects
Improved lipid profiles

Appetite and Metabolism

Unlike some ghrelin mimetics, Ipamorelin shows:

Minimal impact on appetite
No significant hunger stimulation
Improved metabolic flexibility
Better glucose utilization
Enhanced mitochondrial function

Anti-Aging Research

Studies suggest potential for longevity research:

Restoration of youthful GH patterns
Improved skin elasticity markers
Enhanced cellular repair processes
Better sleep quality indicators
Reduced inflammatory markers

Recovery and Repair

Research demonstrates enhanced recovery:

Faster wound healing
Improved muscle recovery
Better connective tissue repair
Enhanced post-exercise recovery
Reduced recovery time from injuries

Potential Side Effects in Research

Ipamorelin shows an exceptional safety profile:

Minimal Side Effects

Very well-tolerated in animal studies

No Cortisol Elevation

Unlike many GH secretagogues

No Prolactin Increase

Maintains hormonal balance

Injection Site

Occasional mild reactions

No Appetite Stimulation

Unlike full ghrelin agonists

No Desensitization

Maintains effectiveness over time

This clean profile makes Ipamorelin ideal for long-term research studies.

IMPORTANT: This product is exclusively for laboratory research purposes and is not approved for human or veterinary use.

References

  1. Raun K, et al. “Ipamorelin, the first selective growth hormone secretagogue.” Eur J Endocrinol. 1998.
  2. Liu S, et al. “The GHS-R1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets.” Eur J Pharmacol. 2024.
  3. Andersen NB, et al. “The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation.” J Endocrinol. 2001.
  4. Beck DE, et al. “Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin.” J Surg Res. 2014.
  5. Johansen PB, et al. “Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth.” Growth Horm IGF Res. 1999.
  6. Salmaso V, et al. “Analysis of the Dynamics of the Human Growth Hormone Secretagogue Receptor.” Angew Chem. 2023.
  7. Svensson J, et al. “The GH secretagogues ipamorelin and GH-releasing peptide-6.” Eur J Endocrinol. 1998.
  8. Sigalos JT, Pastuszak AW. “The Safety and Efficacy of Growth Hormone Secretagogues.” Sex Med Rev. 2018.
  9. Isgaard J, et al. “GH secretagogues: Focus on cardiovascular effects.” Cardiovasc Drug Rev. 2003.
  10. Broglio F, et al. “Growth hormone secretagogues: Focus on the ghrelin system.” Pharmacol Res. 2020.
✓ THIRD-PARTY LAB TESTED

Certificate of Analysis

Independent laboratory testing confirms purity and composition

99.765%
Purity
38HBE
Batch
October 2025
Date
View Certificate →
Weight0.08 lbs
Dimensions0.87 × 1.18 × 0.87 in
Size

5mg, 10mg

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