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DSIP

DSIP

Price range: $55.00 through $90.00

Research suggests DSIP promotes deeper, more restorative sleep by enhancing slow-wave delta patterns. Studies show this naturally occurring peptide may help lower elevated cortisol levels, supporting balanced stress responses. Scientists have also explored its potential for pain modulation and neuroprotective properties, with animal studies demonstrating improved motor recovery. DSIP works differently than melatonin, targeting sleep quality rather than just timing.

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Overview

Delta Sleep-Inducing Peptide (DSIP) is one of nature’s most intriguing sleep regulators. Despite its name suggesting a simple sleep-inducing function, research has revealed DSIP to be a sophisticated neuromodulator with effects reaching far beyond sleep. This peptide acts more like a conductor of an orchestra, harmonizing various physiological systems including sleep-wake cycles, stress responses, pain perception, and immune function. Its ability to cross the blood-brain barrier makes it particularly valuable for neuroscience research.

This product is strictly for research purposes only. Not approved for human or animal use.

Key Characteristics

MOLECULAR PROFILE

Formula: C35H48N10O15

Weight: 848.81 g/mol

CAS: 62568-57-4

Structure: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu

PHYSICAL PROPERTIES

Form: White lyophilized powder

Solubility: Water-soluble

BBB Penetration: Crosses blood-brain barrier

Storage: Keep refrigerated 36‑46 °F (2‑8 °C)

How It Works

DSIP operates through multiple sophisticated mechanisms that orchestrate sleep, stress response, and various physiological systems.

Primary Mechanisms

Neurotransmitter Modulation

Influences glutamate, GABA, and serotonin systems

HPA Axis Regulation

Modulates hypothalamic-pituitary-adrenal responses

Circadian Rhythm Entrainment

Helps synchronize biological clocks

Sleep-Specific Actions

Slow-Wave Sleep Promotion

Enhances deep, restorative sleep phases

Sleep Architecture Normalization

Improves overall sleep structure and balance

Sleep Spindle Enhancement

Increases sleep spindle activity and continuity

Research Findings

Research has uncovered DSIP’s diverse effects across multiple physiological systems, revealing its sophisticated role as a neuromodulator.

Sleep Enhancement

Studies demonstrate significant sleep improvements:

Increased slow-wave (deep) sleep duration
Improved sleep efficiency and quality
Reduced sleep onset latency
Better sleep continuity with fewer awakenings
More refreshing sleep without morning grogginess

Stress Response Modulation

Research shows stress-protective effects:

Reduced cortisol levels under stress
Better adaptation to chronic stress
Improved stress resilience
Protection against stress-induced damage
Normalized autonomic nervous system responses

Neuroprotective Properties

Studies reveal brain-protective benefits:

Protection against excitotoxicity
Reduced oxidative stress in neurons
Improved recovery from brain injury
Enhanced neuronal survival
Potential benefits in neurodegenerative models

Pain Modulation

Research indicates analgesic properties:

Increased pain threshold
Reduced chronic pain perception
Modulation of pain processing pathways
Synergy with endogenous pain control systems
Non-addictive pain relief mechanisms

Immune System Effects

Studies show immunomodulatory actions:

Enhanced immune response during sleep
Better antibody production
Improved T-cell function
Reduced inflammatory markers
Protection against immune suppression

Metabolic & Cardiovascular Effects

Research suggests systemic benefits:

Improved glucose metabolism
Better insulin sensitivity
Blood pressure normalization
Improved heart rate variability
Enhanced vascular function

Potential Side Effects in Research

DSIP generally shows good tolerability with minimal effects. The natural occurrence of DSIP in the body contributes to its favorable safety profile.

Headache

Occasional mild headaches reported

Dizziness

Rare instances of light-headedness

Gastrointestinal

Infrequent mild GI discomfort

Allergic Reactions

Very rare hypersensitivity

No Dependency

No evidence of tolerance or addiction

No Rebound

No rebound insomnia upon cessation

The natural occurrence of DSIP in the body contributes to its favorable safety profile.

IMPORTANT: This product is exclusively for laboratory research purposes and is not approved for human or veterinary use.

References

  1. Luthringer R, et al. “Delta sleep-inducing peptide (DSIP): a still unresolved riddle.” J Psychiatr Res. 2006.
  2. Khvatova EM, et al. “Delta sleep inducing peptide (DSIP): An overview.” Neurosci Biobehav Rev. 1995.
  3. Sudakov KV, et al. “Delta-sleep inducing peptide and neuronal activity after glutamate microiontophoresis.” Neurosci Behav Physiol. 2001.
  4. Graf MV, et al. “Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke.” Molecules. 2021.
  5. Chen L, et al. “Neuropeptides in sleep regulation: Emerging therapeutic targets.” Sleep Med Rev. 2024.
  6. Gangwar A, et al. “Phosphorylated DSIP restores spatial memory and p-CREB expression at high altitude.” Life Sci. 2018.
  7. Iyer KS, McCann SM. “Delta sleep inducing peptide (DSIP) stimulates growth hormone release.” Neuroendocrinology. 1987.
  8. Koplik EV, et al. “DSIP and Deltaran as Approaches to Antistress Protection.” Neurosci Behav Physiol. 2022.
  9. Walleus H, et al. “Delta-sleep-inducing peptide modulates cytokine expression.” J Neuroimmunol. 1995.
  10. Yukhananov RY, et al. “DSIP: Interaction with opioid system.” Pharmacol Biochem Behav. 1992.
✓ THIRD-PARTY LAB TESTED

Certificate of Analysis

Independent laboratory testing confirms purity and composition

98.315%
Purity
17HBE
Batch
August 2025
Date
View Certificate →
Weight 0.08 lbs
Dimensions 0.87 × 1.18 × 0.87 in
Size

5mg, 10mg
SKU: OATH-DSIP Category: Tags: ,
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