CJC-1295

CJC-1295

Price range: $100.00 through $160.00

CJC-1295 (no DAC) is a synthetic peptide designed for research into growth hormone regulation and pulsatile hormone release patterns. This modified version of growth hormone-releasing hormone (GHRH) features a 29-amino acid structure engineered for enhanced stability, making it an important tool for studying endocrine system dynamics and metabolic processes. With its shorter half-life compared to the DAC version, CJC-1295 allows researchers to investigate natural hormone cycling and receptor biology with greater precision.

This research compound requires reconstitution before laboratory use and is exclusively intended for scientific investigation. CJC-1295 (no DAC) is not approved for human or animal consumption and should only be handled by qualified researchers in appropriate laboratory settings.

Overview

Think of CJC-1295 (no DAC) as a precision key designed to unlock specific doors in the body’s hormone control center. Just as a master key can access multiple locks while maintaining security, this synthetic peptide mimics the body’s natural growth hormone-releasing hormone (GHRH) to trigger carefully timed hormone releases. The “no DAC” designation means this version lacks the drug affinity complex that would otherwise extend its active period, allowing researchers to study shorter, more natural hormone pulses.

This research peptide represents a refined tool for investigating how the body regulates growth hormone production. By replicating the first 29 amino acids of natural GHRH with strategic modifications, CJC-1295 provides scientists with a controlled method to explore endocrine system function and metabolic regulation.

This product is strictly for research purposes only. Not approved for human or animal use.

Key Characteristics

MOLECULAR PROFILE

Formula: C152H252N44O42

Weight: ~3,368 g/mol

CAS: 446036-97-1

Structure: 29 amino acids with 4 strategic substitutions

PHYSICAL PROPERTIES

Form: Lyophilized powder

Solubility: Soluble in water

Half-life: Approximately 30 minutes

Storage: Keep refrigerated 36‑46 °F (2‑8 °C)

How It Works

CJC-1295 (no DAC) operates by binding to growth hormone secretagogue receptors in the pituitary gland, much like a specialized messenger delivering instructions to a command center.

Primary Mechanisms

Receptor Binding

Attaches to growth hormone secretagogue receptors, triggering G-protein activation and downstream signaling cascades

Enhanced Stability

Four amino acid substitutions, particularly D-Alanine at position 2, protect from enzyme degradation

Research Benefits

Pulsatile Pattern

Maintains natural hormone release rhythms, ideal for studying endocrine cycling

Short Duration

30-minute half-life allows precise timing of experimental protocols

Research Findings

Laboratory investigations have provided valuable insights into CJC-1295’s biological activity and research applications.

Growth Hormone Regulation Studies

Laboratory investigations have demonstrated that CJC-1295 effectively stimulates growth hormone release in primary rat anterior pituitary cells across a wide concentration range, from picomolar to micromolar levels.

Validated biological activity in cell cultures
Dose-dependent hormone release observed
Successful subcutaneous administration at 1 µmol/kg

Pulsatile Release Patterns

Research indicates that CJC-1295 (no DAC) maintains the natural pulsatile pattern of growth hormone release, making it valuable for studying normal endocrine rhythms.

Preserves physiological hormone cycling
Allows investigation of metabolic rhythms
Avoids continuous stimulation effects

Receptor Biology Applications

The peptide has proven useful for examining growth hormone secretagogue receptor function and downstream signaling pathways.

Predictable binding patterns
Reliable activation kinetics
Useful for receptor mapping studies

Metabolic Research

Scientific studies utilizing CJC-1295 (no DAC) have explored its effects on body composition, muscle protein synthesis, and metabolic function in laboratory models.

Body composition analysis
Protein synthesis investigation
Metabolic pathway mapping

Potential Side Effects in Research

During laboratory studies, researchers have observed various responses to CJC-1295 administration in test subjects:

Local Reactions

Injection site reactions in animal models

Metabolic Changes

Temporary fluctuations in blood glucose levels

Fluid Balance

Water retention in some test subjects

Behavioral Effects

Changes in appetite patterns

Energy Levels

Mild fatigue following administration

Hormonal Response

Transient increases in cortisol levels

These effects appear to be dose-dependent and generally resolve after the peptide’s active period.

IMPORTANT: This product is exclusively for laboratory research and not for human or animal use.

Third-Party Lab Tested

View our independent laboratory test certificate showing purity and composition analysis.


📋 View Test Certificate →

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