Cagrilintide

Cagrilintide

$195.00

Cagrilintide is an innovative research peptide designed as a long-acting version of amylin, a natural hormone that helps regulate appetite and blood sugar. Think of it as an upgraded version of your body’s own appetite control system, engineered to last longer and work more effectively. This synthetic peptide has shown promising results in metabolic research, particularly in studies exploring weight management and glucose regulation. Researchers are investigating its potential for understanding how the body controls hunger signals and processes energy.

This lyophilized powder requires reconstitution before research use and is exclusively intended for laboratory investigation. Cagrilintide represents a significant advancement in peptide research, offering scientists a tool to explore metabolic pathways with enhanced stability and duration compared to natural amylin. This product is strictly for research purposes and is not approved for human or animal consumption.

Overview

Imagine your body has a natural “fullness signal” that tells your brain when you’ve had enough to eat – that’s amylin. Now picture scientists creating a super-charged version of this signal that lasts much longer and works more effectively. That’s Cagrilintide – a cutting-edge research peptide that mimics and enhances your body’s natural appetite control system.

Cagrilintide is a synthetic analog of amylin, specifically engineered to overcome the limitations of the natural hormone. While regular amylin breaks down quickly in the body, Cagrilintide has been modified to stick around longer, giving researchers more time to study its effects on metabolism and appetite regulation. This product is exclusively for laboratory research and not for human or animal use.

This product is strictly for research purposes only. Not approved for human or animal use.

Key Characteristics

MOLECULAR PROFILE

Formula: C194H312N54O59S2

Weight: 4,409 g/mol

CAS: 1415456-99-3

Structure: Modified amylin analog

PHYSICAL PROPERTIES

Form: White lyophilized powder

Solubility: Soluble in water

Half-life: Extended compared to native amylin

Storage: Keep refrigerated 36‑46 °F (2‑8 °C)

How It Works

Cagrilintide works like a master key that fits into special locks (receptors) in your brain, particularly in an area called the area postrema – think of it as your body’s “appetite control center.” When Cagrilintide binds to these receptors, it sends signals that can influence how hungry you feel and how your body processes food.

Primary Mechanisms

Brain Signaling

It activates amylin receptors in specific brain regions that control appetite and food intake

Digestive Regulation

It may slow down how quickly food moves through your stomach, helping maintain feelings of fullness

Metabolic Effects

Glucose Metabolism

It can influence how your body handles glucose and energy metabolism

Enhanced Stability

While natural amylin might work for minutes, Cagrilintide can remain active for hours, providing researchers with extended observation windows

Research Findings

Studies have explored Cagrilintide’s potential in understanding metabolic processes, weight management, and glucose homeostasis. Research has provided valuable insights into amylin receptor activation and metabolic regulation.

Metabolic Research Applications

Studies have explored Cagrilintide’s potential in understanding metabolic processes. Research has shown it may offer insights into:

How the body regulates appetite and satiety signals
The relationship between amylin signaling and glucose metabolism
Long-term metabolic adaptations to peptide interventions

Weight Management Studies

Several clinical investigations have examined Cagrilintide’s effects on body weight regulation. Key findings include:

Enhanced receptor activation compared to native amylin
Sustained metabolic effects due to improved stability
Potential synergistic effects when combined with other research compounds

Diabetes Research

Researchers have investigated Cagrilintide’s role in glucose homeostasis:

Effects on postprandial (after-meal) glucose levels
Interactions with insulin signaling pathways
Long-term metabolic outcomes in diabetic models

Potential Side Effects in Research

During research studies, scientists have observed various responses to Cagrilintide administration. These observations help researchers better understand the peptide’s biological activity and optimal research protocols.

Gastrointestinal Effects

Changes in digestive patterns or gastric emptying rates

Injection Site Reactions

Local responses at administration sites in research models

Metabolic Changes

Alterations in glucose levels or energy metabolism

Appetite Modifications

Changes in feeding behavior in research subjects

These observations help researchers better understand the peptide’s biological activity and optimal research protocols.

IMPORTANT: This product is exclusively for laboratory research purposes and is not approved for human or veterinary use.

References

  1. Enebo, L. B., et al. (2021). “Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2·4 mg for weight management: a randomised, controlled, phase 1b trial.” The Lancet, 397(10286), 1736-1748.
  2. Lau, D. C., et al. (2021). “Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial.” The Lancet, 398(10317), 2160-2172.
  3. Frias, J. P., et al. (2023). “Efficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial.” The Lancet, 402(10403), 720-730.
  4. Wharton S, et al. “CagriSema for obesity management: SURMOUNT-5 trial design and rationale.” Obesity (Silver Spring). 2024.
  5. Kadowaki T, et al. “Cagrilintide/semaglutide (CagriSema) combination for obesity: A systematic review.” Diabetes Obes Metab. 2024.
  6. Drucker DJ. “Amylin analogues for obesity: New advances with cagrilintide.” Cell Metab. 2023.

Third-Party Lab Tested

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Size

10mg
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