Sermorelin Peptide: Why does sleep affect Sermorelin? It’s a fantastic question and one that gets right to the heart of what makes this particular peptide so fascinating. Here at Oath Research, we love diving into the “why” behind the science, and the relationship between Sermorelin, your body’s natural rhythms, and sleep is a perfect example of elegant biological synergy. To truly understand it, we need to look at how our bodies are already programmed to work, especially when the lights go out.
So, let’s pull back the curtain on this intricate dance. Sermorelin isn’t some foreign compound that hijacks your system; it’s a clever biomimetic tool. Specifically, it’s a peptide analog of growth hormone-releasing hormone (GHRH). In simple terms, it’s a synthetic version of the first 29 amino acids of the very hormone your brain naturally uses to signal for growth hormone (GH) release. It doesn’t add foreign growth hormone to your body; it gently nudges your own pituitary gland to produce more of its own.
This process is what we call `gh-stimulation`. Instead of overriding the body’s natural feedback loops, Sermorelin works with them. It sends a signal to the `pituitary`, the master gland nestled at the base of your brain, essentially saying, “Hey, it’s time to get to work and release some of that growth hormone you’ve been storing.” This approach maintains the body’s natural pulsatile release of GH, which is crucial for safety and effectiveness.
The Midnight Symphony: Growth Hormone and Sleep
Your body doesn’t release growth hormone in a steady trickle throughout the day. Instead, it happens in pulses, and the largest, most significant pulse of the entire 24-hour cycle occurs shortly after you fall into deep sleep. This phase of `sleep`, known as slow-wave sleep (SWS), is when your body is in prime repair and recovery mode. Think of it as the body’s nightly maintenance crew clocking in for their most important shift.
During this deep sleep window, the brain naturally ramps up its production of GHRH, triggering that major GH release from the pituitary. This flood of growth hormone is responsible for a huge range of restorative processes: repairing muscle tissue damaged from exercise, strengthening bones, synthesizing proteins, and helping regulate metabolism. It’s no coincidence that children do most of their growing while they sleep, and it’s why a night of poor sleep can leave you feeling physically and mentally sluggish—you missed out on your prime repair window.
This natural connection is the absolute key to understanding Sermorelin’s relationship with sleep. The peptide is most effective when it can amplify a process that is already happening. It’s like pouring gasoline on a flickering flame versus trying to light a wet log.
Understanding the Relationship: Why Does Sleep Affect Sermorelin Peptide?
Now we can directly answer the big question. Sleep doesn’t “affect” the Sermorelin peptide molecule itself, but the timing of its administration relative to sleep dramatically affects its efficacy. When Sermorelin is introduced into the system shortly before bedtime, it arrives at the pituitary gland just as the brain is naturally preparing to send its own GHRH signal.
The result is a powerful, synergistic effect. Sermorelin essentially joins forces with your body’s endogenous GHRH, creating a much stronger signal for `gh-stimulation` than either would produce alone. This leads to a more robust and amplified release of growth hormone during that critical deep sleep window. You’re not forcing the body to do something unnatural; you’re supercharging its most important natural process for growth and repair.
A study published in the Journal of Clinical Endocrinology & Metabolism highlighted that GHRH administration significantly amplifies the natural, sleep-related GH secretory bursts [1]. This confirms that these GHRH analogs are working in concert with the body’s circadian rhythm, not against it. Administering Sermorelin at another time of day, like in the morning, would still cause a small GH pulse, but it would miss the opportunity to compound with the body’s most powerful natural release cycle.
The Positive Feedback Loop: Can Sermorelin Improve Sleep?
Here’s where it gets even more interesting: the relationship is a two-way street. While proper sleep timing maximizes Sermorelin’s effects, the resulting increase in growth hormone can, in turn, promote deeper and more restorative sleep. Higher levels of GH are associated with an increase in slow-wave sleep duration and quality.
This can create a beneficial positive feedback loop. Your research protocol involves administering Sermorelin before sleep, which leads to a more significant GH pulse. That enhanced GH level helps improve the quality and depth of your subject’s sleep. Better sleep quality then further supports the body’s natural ability to release GH, creating an upward spiral of improved sleep and optimized hormonal function.
For researchers specifically investigating the mechanisms of sleep itself, this interplay is a rich area of study. Peptides that directly influence sleep architecture, such as the well-researched DSIP, or Delta Sleep-Inducing Peptide, are often studied to understand how different compounds can promote the slow-wave sleep that is so critical for GH release.
Sermorelin, Body Composition, and Anti-Aging: The Bigger Picture
The benefits that researchers often investigate with Sermorelin—improved `body-composition` and potential `anti-aging` effects—are all downstream consequences of this optimized GH release. As GH levels rise overnight, the body’s metabolic and regenerative processes kick into high gear.
For `body-composition`, this translates to two key actions. First, GH stimulates lipolysis, the breakdown of fat cells for energy. Second, it promotes the synthesis of lean muscle tissue. Over time, this dual action can lead to a noticeable shift in a research subject’s ratio of lean mass to body fat.
In the context of `anti-aging` research, GH plays a vital role in cellular health and regeneration. It supports collagen production, which can improve skin thickness and elasticity. It aids in maintaining bone density, a critical factor in aging well. Furthermore, the enhanced recovery and repair it facilitates can lead to increased energy levels and overall vitality. For researchers looking to study this foundational GHRH analog, our high-purity Sermorelin provides a reliable and consistent compound for reproducible results.
Optimizing Your Research Protocol: Why Does Sleep Affect Sermorelin in a Practical Sense?
For any researcher, consistency and controlling variables are paramount. Understanding this peptide’s relationship with sleep allows for the design of a more effective and reliable research protocol.
1. Timing is Key: The most logical administration time for a Sermorelin research study is subcutaneous injection approximately 30-60 minutes before bedtime. This ensures the peptide has reached peak concentration in the bloodstream right as the subject is entering the first stages of deep sleep.
2. Mind the Midnight Snack: Growth hormone release is potently inhibited by high levels of blood sugar and insulin. Administering Sermorelin after a high-carbohydrate or sugary meal or snack would be counterproductive, as the elevated insulin would blunt the pituitary’s response to the GHRH signal. Research protocols should ideally specify administration on an empty stomach, at least 2-3 hours after the last meal.
3. Sleep Hygiene Matters: The efficacy of the protocol relies on the subject actually achieving deep sleep. Factors that disrupt sleep—like blue light from screens, caffeine late in the day, or an inconsistent sleep schedule—can undermine the results. Emphasizing good sleep hygiene is a crucial part of a well-designed study.
4. Considering Combination Research: In advanced research, Sermorelin is often studied alongside a GHRP (Growth Hormone-Releasing Peptide) like Ipamorelin. While Sermorelin (a GHRH) works on one receptor, GHRPs work on a different one (the ghrelin receptor), also stimulating GH release. Using them together, as seen in popular research blends like CJC-1295 with Ipamorelin, can create a powerful 1-2 punch, leading to a much stronger synergistic release of GH than either could achieve alone.
The link between GHRH, its analogs like Sermorelin, and sleep-dependent GH secretion has been a cornerstone of endocrinology research for decades, with studies like one from the journal Sleep demonstrating that GHRH is essential for generating high-amplitude GH pulses during sleep [2]. This solidifies the “why” behind timing your research for maximum impact.
—
Frequently Asked Questions (FAQ)
1. What is Sermorelin peptide in simple terms?
Sermorelin is a synthetic peptide that mimics the body’s natural Growth Hormone-Releasing Hormone (GHRH). It works by stimulating the pituitary gland to produce and release more of its own growth hormone, rather than introducing a synthetic growth hormone into the body.
2. When is the best time to administer Sermorelin for research?
Based on its mechanism, the optimal time for administration in a research setting is shortly before bedtime on an empty stomach. This allows the peptide to work synergistically with the body’s natural, largest pulse of growth hormone release that occurs during deep sleep.
3. Is Sermorelin the same as taking HGH (Human Growth Hormone)?
No, they are fundamentally different. Taking HGH is a form of hormone replacement therapy. Administering Sermorelin is a form of hormone stimulation therapy. Sermorelin encourages your body to make its own GH, which preserves the natural feedback loops and pulsatile release schedule of the pituitary gland.
4. What are the primary areas of Sermorelin research?
Research on Sermorelin often focuses on its potential to improve body composition (increasing lean muscle and decreasing fat), enhance recovery from exercise, improve sleep quality, and for its potential anti-aging effects related to skin health, bone density, and overall vitality.
5. How does diet impact Sermorelin’s effectiveness in a study?
Diet, particularly carbohydrate and sugar intake, has a significant impact. High blood sugar and the resulting insulin spike can blunt or even completely inhibit the pituitary gland’s release of growth hormone. For this reason, Sermorelin should be administered on an empty stomach, away from meals containing sugars or carbs.
6. Can Sermorelin be studied alongside other peptides?
Yes, this is common in advanced research. Sermorelin (a GHRH analog) is often paired with a GHRP (Growth Hormone-Releasing Peptide) like Ipamorelin or GHRP-6. They stimulate GH release through different pathways, and their combined use can result in a synergistic and more potent effect.
7. How does Sermorelin actually work?
Sermorelin, being a fragment of GHRH, binds to the GHRH receptors on the pituitary gland. This binding action initiates a signaling cascade inside the pituitary cells, prompting them to synthesize and release stored growth hormone into the bloodstream.
8. What is the difference between Sermorelin and Tesamorelin?
Both are analogs of GHRH, but Tesamorelin is a more stabilized and longer-acting version. While Sermorelin is a 29-amino-acid chain, Tesamorelin is a 44-amino-acid chain with modifications to make it more resistant to enzymatic breakdown. Both stimulate the pituitary, but Tesamorelin has a longer half-life and is specifically studied for certain metabolic conditions.
9. Why is deep sleep so important for growth hormone release?
The body’s circadian rhythm is hard-wired to perform its most intensive repair and regeneration activities during deep, slow-wave sleep. The brain signals for the largest release of GH during this time to provide the essential hormonal tool for this repair work, including muscle-building, bone strengthening, and cellular turnover. A review in Current Opinion in Endocrinology, Diabetes and Obesity emphasizes this deep link between the sleep-wake cycle and the hypothalamic-pituitary axis [3].
10. How long does it take to observe changes in research subjects?
Sermorelin works by gradually restoring and optimizing the body’s own GH production. Therefore, observable changes in research subjects are typically not immediate. Changes in sleep quality and energy levels might be noted sooner, but alterations in body composition and other markers are generally observed over a period of 3-6 months of consistent research.
11. Does Sermorelin require bacteriostatic water for reconstitution?
Yes. Like most research peptides that come in lyophilized (freeze-dried) powder form, Sermorelin must be reconstituted with a sterile solvent before use in a research setting. Bacteriostatic Water is the standard and appropriate solvent for this purpose.
12. What is the half-life of Sermorelin?
Sermorelin has a very short half-life, typically around 10-12 minutes. This is by design. It delivers its signal to the pituitary quickly and is then rapidly cleared, mimicking the body’s natural pulsatile release of GHRH and preventing overstimulation of the gland.
—
Conclusion: A Partnership with Your Biology
The relationship between Sermorelin and sleep isn’t a fluke; it’s a beautiful example of using scientific innovation to support and enhance our body’s innate wisdom. By understanding that Sermorelin is designed to amplify the most powerful natural GH pulse of the day, we unlock its full research potential. It’s not about fighting against the body’s rhythms, but about partnering with them.
At Oath Research, we’re dedicated to providing the highest-purity compounds to support the important work of the research community. By understanding the “why” and “how” behind peptides like Sermorelin, we can design smarter studies and unlock new insights into human physiology, aging, and performance.
All products sold by Oath Research, including Sermorelin, are strictly intended for laboratory and research use only. They are not for human or animal consumption.
Ready to power your next research project? Explore our catalog of premium-grade peptides and see why researchers trust Oath for quality and consistency.
References
1. Van Cauter, E., Caufriez, A., Kerkhofs, M., Van Onderbergen, A., Thorner, M. O., & Copinschi, G. (1992). Sleep, awakenings, and insulin-like growth factor-I modulate the growth hormone (GH) response to GH-releasing hormone. The Journal of Clinical Endocrinology & Metabolism, 74(6), 1451–1459.
2. Obal, F., Jr, & Krueger, J. M. (2004). GHRH and GHRH receptor antagonists: effects on sleep, body temperature and growth hormone secretion. Sleep, 27(1), 136-143.
3. García-García, F., Juárez-Aguilar, E., & Ramírez-Salado, I. (2012). The hypothalamic-pituitary-adrenal axis and the sleep-wake cycle. Current Opinion in Endocrinology, Diabetes and Obesity, 19(3), 201–206.
Sermorelin Peptide: Why does sleep affect Sermorelin?
Sermorelin Peptide: Why does sleep affect Sermorelin? It’s a fantastic question and one that gets right to the heart of what makes this particular peptide so fascinating. Here at Oath Research, we love diving into the “why” behind the science, and the relationship between Sermorelin, your body’s natural rhythms, and sleep is a perfect example of elegant biological synergy. To truly understand it, we need to look at how our bodies are already programmed to work, especially when the lights go out.
So, let’s pull back the curtain on this intricate dance. Sermorelin isn’t some foreign compound that hijacks your system; it’s a clever biomimetic tool. Specifically, it’s a peptide analog of growth hormone-releasing hormone (GHRH). In simple terms, it’s a synthetic version of the first 29 amino acids of the very hormone your brain naturally uses to signal for growth hormone (GH) release. It doesn’t add foreign growth hormone to your body; it gently nudges your own pituitary gland to produce more of its own.
This process is what we call `gh-stimulation`. Instead of overriding the body’s natural feedback loops, Sermorelin works with them. It sends a signal to the `pituitary`, the master gland nestled at the base of your brain, essentially saying, “Hey, it’s time to get to work and release some of that growth hormone you’ve been storing.” This approach maintains the body’s natural pulsatile release of GH, which is crucial for safety and effectiveness.
The Midnight Symphony: Growth Hormone and Sleep
Your body doesn’t release growth hormone in a steady trickle throughout the day. Instead, it happens in pulses, and the largest, most significant pulse of the entire 24-hour cycle occurs shortly after you fall into deep sleep. This phase of `sleep`, known as slow-wave sleep (SWS), is when your body is in prime repair and recovery mode. Think of it as the body’s nightly maintenance crew clocking in for their most important shift.
During this deep sleep window, the brain naturally ramps up its production of GHRH, triggering that major GH release from the pituitary. This flood of growth hormone is responsible for a huge range of restorative processes: repairing muscle tissue damaged from exercise, strengthening bones, synthesizing proteins, and helping regulate metabolism. It’s no coincidence that children do most of their growing while they sleep, and it’s why a night of poor sleep can leave you feeling physically and mentally sluggish—you missed out on your prime repair window.
This natural connection is the absolute key to understanding Sermorelin’s relationship with sleep. The peptide is most effective when it can amplify a process that is already happening. It’s like pouring gasoline on a flickering flame versus trying to light a wet log.
Understanding the Relationship: Why Does Sleep Affect Sermorelin Peptide?
Now we can directly answer the big question. Sleep doesn’t “affect” the Sermorelin peptide molecule itself, but the timing of its administration relative to sleep dramatically affects its efficacy. When Sermorelin is introduced into the system shortly before bedtime, it arrives at the pituitary gland just as the brain is naturally preparing to send its own GHRH signal.
The result is a powerful, synergistic effect. Sermorelin essentially joins forces with your body’s endogenous GHRH, creating a much stronger signal for `gh-stimulation` than either would produce alone. This leads to a more robust and amplified release of growth hormone during that critical deep sleep window. You’re not forcing the body to do something unnatural; you’re supercharging its most important natural process for growth and repair.
A study published in the Journal of Clinical Endocrinology & Metabolism highlighted that GHRH administration significantly amplifies the natural, sleep-related GH secretory bursts [1]. This confirms that these GHRH analogs are working in concert with the body’s circadian rhythm, not against it. Administering Sermorelin at another time of day, like in the morning, would still cause a small GH pulse, but it would miss the opportunity to compound with the body’s most powerful natural release cycle.
The Positive Feedback Loop: Can Sermorelin Improve Sleep?
Here’s where it gets even more interesting: the relationship is a two-way street. While proper sleep timing maximizes Sermorelin’s effects, the resulting increase in growth hormone can, in turn, promote deeper and more restorative sleep. Higher levels of GH are associated with an increase in slow-wave sleep duration and quality.
This can create a beneficial positive feedback loop. Your research protocol involves administering Sermorelin before sleep, which leads to a more significant GH pulse. That enhanced GH level helps improve the quality and depth of your subject’s sleep. Better sleep quality then further supports the body’s natural ability to release GH, creating an upward spiral of improved sleep and optimized hormonal function.
For researchers specifically investigating the mechanisms of sleep itself, this interplay is a rich area of study. Peptides that directly influence sleep architecture, such as the well-researched DSIP, or Delta Sleep-Inducing Peptide, are often studied to understand how different compounds can promote the slow-wave sleep that is so critical for GH release.
Sermorelin, Body Composition, and Anti-Aging: The Bigger Picture
The benefits that researchers often investigate with Sermorelin—improved `body-composition` and potential `anti-aging` effects—are all downstream consequences of this optimized GH release. As GH levels rise overnight, the body’s metabolic and regenerative processes kick into high gear.
For `body-composition`, this translates to two key actions. First, GH stimulates lipolysis, the breakdown of fat cells for energy. Second, it promotes the synthesis of lean muscle tissue. Over time, this dual action can lead to a noticeable shift in a research subject’s ratio of lean mass to body fat.
In the context of `anti-aging` research, GH plays a vital role in cellular health and regeneration. It supports collagen production, which can improve skin thickness and elasticity. It aids in maintaining bone density, a critical factor in aging well. Furthermore, the enhanced recovery and repair it facilitates can lead to increased energy levels and overall vitality. For researchers looking to study this foundational GHRH analog, our high-purity Sermorelin provides a reliable and consistent compound for reproducible results.
Optimizing Your Research Protocol: Why Does Sleep Affect Sermorelin in a Practical Sense?
For any researcher, consistency and controlling variables are paramount. Understanding this peptide’s relationship with sleep allows for the design of a more effective and reliable research protocol.
1. Timing is Key: The most logical administration time for a Sermorelin research study is subcutaneous injection approximately 30-60 minutes before bedtime. This ensures the peptide has reached peak concentration in the bloodstream right as the subject is entering the first stages of deep sleep.
2. Mind the Midnight Snack: Growth hormone release is potently inhibited by high levels of blood sugar and insulin. Administering Sermorelin after a high-carbohydrate or sugary meal or snack would be counterproductive, as the elevated insulin would blunt the pituitary’s response to the GHRH signal. Research protocols should ideally specify administration on an empty stomach, at least 2-3 hours after the last meal.
3. Sleep Hygiene Matters: The efficacy of the protocol relies on the subject actually achieving deep sleep. Factors that disrupt sleep—like blue light from screens, caffeine late in the day, or an inconsistent sleep schedule—can undermine the results. Emphasizing good sleep hygiene is a crucial part of a well-designed study.
4. Considering Combination Research: In advanced research, Sermorelin is often studied alongside a GHRP (Growth Hormone-Releasing Peptide) like Ipamorelin. While Sermorelin (a GHRH) works on one receptor, GHRPs work on a different one (the ghrelin receptor), also stimulating GH release. Using them together, as seen in popular research blends like CJC-1295 with Ipamorelin, can create a powerful 1-2 punch, leading to a much stronger synergistic release of GH than either could achieve alone.
The link between GHRH, its analogs like Sermorelin, and sleep-dependent GH secretion has been a cornerstone of endocrinology research for decades, with studies like one from the journal Sleep demonstrating that GHRH is essential for generating high-amplitude GH pulses during sleep [2]. This solidifies the “why” behind timing your research for maximum impact.
—
Frequently Asked Questions (FAQ)
1. What is Sermorelin peptide in simple terms?
Sermorelin is a synthetic peptide that mimics the body’s natural Growth Hormone-Releasing Hormone (GHRH). It works by stimulating the pituitary gland to produce and release more of its own growth hormone, rather than introducing a synthetic growth hormone into the body.
2. When is the best time to administer Sermorelin for research?
Based on its mechanism, the optimal time for administration in a research setting is shortly before bedtime on an empty stomach. This allows the peptide to work synergistically with the body’s natural, largest pulse of growth hormone release that occurs during deep sleep.
3. Is Sermorelin the same as taking HGH (Human Growth Hormone)?
No, they are fundamentally different. Taking HGH is a form of hormone replacement therapy. Administering Sermorelin is a form of hormone stimulation therapy. Sermorelin encourages your body to make its own GH, which preserves the natural feedback loops and pulsatile release schedule of the pituitary gland.
4. What are the primary areas of Sermorelin research?
Research on Sermorelin often focuses on its potential to improve body composition (increasing lean muscle and decreasing fat), enhance recovery from exercise, improve sleep quality, and for its potential anti-aging effects related to skin health, bone density, and overall vitality.
5. How does diet impact Sermorelin’s effectiveness in a study?
Diet, particularly carbohydrate and sugar intake, has a significant impact. High blood sugar and the resulting insulin spike can blunt or even completely inhibit the pituitary gland’s release of growth hormone. For this reason, Sermorelin should be administered on an empty stomach, away from meals containing sugars or carbs.
6. Can Sermorelin be studied alongside other peptides?
Yes, this is common in advanced research. Sermorelin (a GHRH analog) is often paired with a GHRP (Growth Hormone-Releasing Peptide) like Ipamorelin or GHRP-6. They stimulate GH release through different pathways, and their combined use can result in a synergistic and more potent effect.
7. How does Sermorelin actually work?
Sermorelin, being a fragment of GHRH, binds to the GHRH receptors on the pituitary gland. This binding action initiates a signaling cascade inside the pituitary cells, prompting them to synthesize and release stored growth hormone into the bloodstream.
8. What is the difference between Sermorelin and Tesamorelin?
Both are analogs of GHRH, but Tesamorelin is a more stabilized and longer-acting version. While Sermorelin is a 29-amino-acid chain, Tesamorelin is a 44-amino-acid chain with modifications to make it more resistant to enzymatic breakdown. Both stimulate the pituitary, but Tesamorelin has a longer half-life and is specifically studied for certain metabolic conditions.
9. Why is deep sleep so important for growth hormone release?
The body’s circadian rhythm is hard-wired to perform its most intensive repair and regeneration activities during deep, slow-wave sleep. The brain signals for the largest release of GH during this time to provide the essential hormonal tool for this repair work, including muscle-building, bone strengthening, and cellular turnover. A review in Current Opinion in Endocrinology, Diabetes and Obesity emphasizes this deep link between the sleep-wake cycle and the hypothalamic-pituitary axis [3].
10. How long does it take to observe changes in research subjects?
Sermorelin works by gradually restoring and optimizing the body’s own GH production. Therefore, observable changes in research subjects are typically not immediate. Changes in sleep quality and energy levels might be noted sooner, but alterations in body composition and other markers are generally observed over a period of 3-6 months of consistent research.
11. Does Sermorelin require bacteriostatic water for reconstitution?
Yes. Like most research peptides that come in lyophilized (freeze-dried) powder form, Sermorelin must be reconstituted with a sterile solvent before use in a research setting. Bacteriostatic Water is the standard and appropriate solvent for this purpose.
12. What is the half-life of Sermorelin?
Sermorelin has a very short half-life, typically around 10-12 minutes. This is by design. It delivers its signal to the pituitary quickly and is then rapidly cleared, mimicking the body’s natural pulsatile release of GHRH and preventing overstimulation of the gland.
—
Conclusion: A Partnership with Your Biology
The relationship between Sermorelin and sleep isn’t a fluke; it’s a beautiful example of using scientific innovation to support and enhance our body’s innate wisdom. By understanding that Sermorelin is designed to amplify the most powerful natural GH pulse of the day, we unlock its full research potential. It’s not about fighting against the body’s rhythms, but about partnering with them.
At Oath Research, we’re dedicated to providing the highest-purity compounds to support the important work of the research community. By understanding the “why” and “how” behind peptides like Sermorelin, we can design smarter studies and unlock new insights into human physiology, aging, and performance.
All products sold by Oath Research, including Sermorelin, are strictly intended for laboratory and research use only. They are not for human or animal consumption.
Ready to power your next research project? Explore our catalog of premium-grade peptides and see why researchers trust Oath for quality and consistency.
References
1. Van Cauter, E., Caufriez, A., Kerkhofs, M., Van Onderbergen, A., Thorner, M. O., & Copinschi, G. (1992). Sleep, awakenings, and insulin-like growth factor-I modulate the growth hormone (GH) response to GH-releasing hormone. The Journal of Clinical Endocrinology & Metabolism, 74(6), 1451–1459.
2. Obal, F., Jr, & Krueger, J. M. (2004). GHRH and GHRH receptor antagonists: effects on sleep, body temperature and growth hormone secretion. Sleep, 27(1), 136-143.
3. García-García, F., Juárez-Aguilar, E., & Ramírez-Salado, I. (2012). The hypothalamic-pituitary-adrenal axis and the sleep-wake cycle. Current Opinion in Endocrinology, Diabetes and Obesity, 19(3), 201–206.