The Sermorelin peptide represents a groundbreaking area of study in the world of longevity and wellness, often hailed by researchers as a potential key to unlocking the body’s own anti-aging mechanisms. Unlike introducing foreign hormones, Sermorelin works by tapping into the body’s innate systems, encouraging a more youthful and efficient physiological state. As we delve into the science behind this fascinating compound, we’ll explore how it’s being investigated for everything from improved body composition to deeper, more restorative sleep.
At Oath Research, we’re dedicated to providing the highest-purity peptides for your laboratory investigations. Understanding the intricate mechanisms of compounds like Sermorelin is crucial for designing effective and insightful studies.
Unlocking the Pituitary: How Sermorelin Works
Sermorelin is a synthetic peptide analog of the naturally occurring Growth Hormone-Releasing Hormone (GHRH). In simple terms, it’s a molecular mimic. Its structure is comprised of the first 29 amino acids of endogenous GHRH, which is the exact portion of the hormone responsible for its biological activity. This makes it a powerful tool for initiating a very specific chain of events within the body.
The primary target of Sermorelin is the pituitary gland, a small, pea-sized gland located at the base of the brain, often called the “master gland” for its role in regulating numerous bodily functions. When Sermorelin is introduced in a research setting, it binds to GHRH receptors on the surface of the pituitary gland. This binding acts as a signal, a gentle “nudge,” prompting the pituitary to naturally produce and release its own stores of Human Growth Hormone (HGH).
This mechanism of GH-stimulation is what sets Sermorelin apart from other approaches. It doesn’t introduce synthetic HGH into the system. Instead, it supports the body’s own ability to manufacture and secrete HGH. This process preserves the natural, pulsatile release of growth hormone—the rhythmic bursts that primarily occur during deep sleep and after intense exercise, which is characteristic of a youthful endocrine system.
The Sermorelin Peptide: Restoring a Natural Rhythm
As organisms age, the communication between the hypothalamus (which produces GHRH) and the pituitary gland can become less efficient. This decline in GHRH signaling contributes to a state known as somatopause, the age-related decline in HGH levels. This reduction is linked to many of the classic signs of aging: decreased muscle mass, increased body fat, lower energy levels, and diminished skin quality.
Sermorelin is studied for its potential to counteract this decline by directly stimulating the pituitary. It effectively bypasses any potential shortfall in the hypothalamus’s GHRH production. By re-engaging the pituitary gland, Sermorelin helps restore a more youthful pattern of HGH secretion. This approach ensures that the body’s intricate hormonal feedback loops remain intact. The body can still use somatostatin (the hormone that inhibits GH release) to regulate HGH levels, preventing them from becoming excessively high. This built-in safety mechanism is a key focus of Sermorelin research.
A Deeper Dive into Sermorelin’s Anti-Aging Potential
The term anti-aging is broad, but in the context of peptide research, it refers to a set of measurable physiological improvements that promote healthspan and vitality. Sermorelin’s ability to optimize HGH levels places it at the center of this research, with studies exploring its influence on several key biomarkers of aging.
One of the most visible areas of interest is skin health. HGH plays a critical role in cellular regeneration and the synthesis of collagen, the protein that gives skin its structure and firmness. As HGH levels decline with age, so does collagen production, leading to thinner, less elastic skin and the formation of wrinkles. By promoting endogenous HGH, Sermorelin is being investigated for its potential to support skin cell turnover, improve hydration, and enhance overall skin thickness and resilience.
Beyond the skin, researchers are focused on the systemic effects. Optimized HGH levels are linked to improved energy and vitality. This isn’t just a subjective feeling; it’s tied to HGH’s role in metabolism and cellular repair. Many pre-clinical models suggest that restoring a more youthful HGH profile can lead to increased stamina, reduced fatigue, and a greater overall sense of well-being.
Furthermore, HGH receptors are found throughout the body, including the immune system and the brain. Studies are ongoing to determine how stimulating natural HGH release with Sermorelin could support immune function and even enhance cognitive processes like memory and focus, which often decline with age. One comprehensive review published in Clinical Interventions in Aging notes the wide-ranging effects that restoring GH levels can have, reinforcing its importance in anti-aging strategies (1).
Optimizing Body Composition with the Sermorelin Peptide
One of the most compelling areas of Sermorelin research is its effect on body-composition. The age-related shift toward increased adiposity (body fat), particularly visceral fat around the organs, and decreased lean muscle mass (sarcopenia) is a major health concern. HGH is a powerful metabolic hormone that directly influences this balance.
HGH promotes lipolysis, which is the breakdown of stored triglycerides in fat cells (adipocytes) into free fatty acids. These fatty acids can then be used by the body for energy. By naturally elevating HGH levels, Sermorelin is studied for its ability to accelerate fat loss, especially when combined with a proper diet and exercise regimen in research subjects.
Simultaneously, HGH exhibits anabolic (muscle-building) properties. It promotes the uptake of amino acids into muscle cells and stimulates the synthesis of new muscle protein. This can help preserve, and in some cases even increase, lean muscle mass. The combined effect of reducing fat mass while maintaining or building muscle leads to a dramatic improvement in overall body-composition. A landmark study in the Journal of Clinical Endocrinology & Metabolism demonstrated that Sermorelin administration in GH-deficient men led to an increase in lean body mass and a trend toward a decrease in adipose tissue (2).
This dual-action effect makes Sermorelin peptide research highly relevant for studies focused not just on weight loss, but on PODY recomposition—creating a stronger, leaner, and more metabolically healthy physique.
The Critical Link Between Sermorelin, HGH, and Sleep
The relationship between HGH and sleep is a fascinating and bidirectional one. The majority of the body’s daily HGH is released during the deepest stage of sleep, known as slow-wave sleep (SWS). As we age, the amount of time we spend in SWS decreases, which in turn leads to lower HGH secretion. This creates a challenging cycle: less deep sleep means less HGH, and lower HGH levels can further disrupt sleep architecture.
Sermorelin research aims to break this cycle. By providing a GHRH signal before bedtime in a research setting, it can stimulate the pituitary to release a significant pulse of HGH, mimicking the natural process that should occur during SWS. This has led to studies exploring Sermorelin not just as a GH stimulant, but as a potential tool for improving sleep quality.
Researchers have found that subjects in these studies often report falling asleep faster and experiencing deeper, more restorative sleep. They wake up feeling more refreshed and energized. A notable study on older men found that Sermorelin administration not only increased HGH but also significantly improved the quality of sleep, suggesting a direct link between the peptide’s action and sleep regulation (3). By restoring this crucial HGH pulse, Sermorelin may help re-establish a healthier and more youthful sleep pattern, which has cascading benefits for cognitive function, recovery, and overall health.
Sermorelin in the Landscape of GHRH Analogs
Sermorelin is often considered the foundational GHRH analog, but it’s not the only one. The field of peptide research has produced other molecules with similar mechanisms but different characteristics. Understanding these differences is key for researchers selecting the right compound for their study.
One of the most well-known alternatives is CJC-1295. While both Sermorelin and CJC-1295 stimulate the pituitary gland, their primary difference lies in their half-life. Sermorelin has a very short half-life, typically around 10-12 minutes. This results in a sharp, quick pulse of HGH, closely mimicking the body’s natural pulsatile release. This makes it ideal for studies aiming to replicate this specific physiological event, such as a large release before sleep.
In contrast, researchers interested in a more sustained elevation of HGH might explore other GHRH analogs like CJC-1295. This peptide is modified to be more resistant to enzymatic degradation, giving it a much longer half-life. This results in a continuous, elevated baseline of HGH, often referred to as a “GH bleed,” rather than sharp pulses. The choice between Sermorelin and CJC-1295 depends entirely on the specific goals and parameters of the research project.
For a synergistic effect, many researchers combine a GHRH with a Growth Hormone Releasing Peptide (GHRP), such as Ipamorelin. While GHRHs stimulate the pituitary at one receptor, GHRPs work on a different receptor (the ghrelin receptor) to also stimulate HGH release and suppress somatostatin. Using them together creates a powerful, synergistic pulse of HGH that is greater than the sum of its parts. This is why you will often see popular research combinations like CJC-1295 with Ipamorelin being used to achieve maximum GH secretion in a research model.
Proper Handling and Reconstitution for Research
To ensure the integrity and efficacy of your research, proper handling of lyophilized peptides is paramount. Peptides like our high-purity Sermorelin acetate are delivered in a freeze-dried powder state to ensure maximum stability and shelf-life. They must be reconstituted before use in any experiment.
The process involves carefully introducing a sterile diluent, such as Bacteriostatic Water, into the vial. Bacteriostatic water is sterile water that contains 0.9% benzyl alcohol as a preservative, which allows for multiple withdrawals from the same vial while maintaining sterility. The liquid should be gently directed down the side of the vial, not directly onto the lyophilized powder, to prevent damaging the delicate peptide chains. The vial should then be gently swirled or rolled—never shaken—until the powder is fully dissolved. Once reconstituted, the peptide solution should be stored under refrigeration and used within the timeframe recommended for that specific peptide to ensure its potency.
Frequently Asked Questions (FAQ)
Q1: What is the primary function of Sermorelin in research?
A: In a research context, Sermorelin’s primary function is to act as a Growth Hormone-Releasing Hormone (GHRH) analog. It is used to stimulate the pituitary gland to naturally produce and release its own Human Growth Hormone (HGH). This allows researchers to study the downstream effects of optimized HGH levels on various physiological processes, such as metabolism, cellular repair, body composition, and sleep.
Q2: How does Sermorelin’s mechanism differ from that of synthetic HGH?
A: The difference is fundamental. Synthetic HGH introduces an external supply of the hormone directly into the bloodstream, bypassing the body’s regulatory systems. Sermorelin, on the other hand, works upstream by stimulating the pituitary gland. This preserves the body’s natural feedback loops, including the inhibitory action of somatostatin, and promotes a pulsatile release of HGH, which is considered a more bio-identical approach.
Q3: What is the significance of Sermorelin’s short half-life?
A: Sermorelin’s short half-life (about 10-12 minutes) means it is cleared from the system quickly. This results in a sharp, defined pulse of HGH release rather than a sustained elevation. This characteristic is highly valued by researchers looking to mimic the body’s natural, episodic release of HGH, particularly the large pulse that occurs during deep sleep.
Q4: Why is the Sermorelin peptide so prominently studied for anti-aging?
A: Sermorelin is a key focus in anti-aging research because it addresses a primary driver of aging—the decline of HGH, or somatopause. By promoting the body’s own HGH production, it allows scientists to investigate the reversal or slowing of many age-related markers, including loss of muscle mass, increased body fat, decreased skin elasticity, poor sleep quality, and reduced vitality, all without introducing an external hormone.
Conclusion: The Future of Anti-Aging Research
The Sermorelin peptide continues to be a cornerstone of modern anti-aging and wellness research. Its unique ability to stimulate the body’s own production of HGH in a safe and physiologically natural way provides a powerful tool for scientists. From enhancing body-composition by favoring lean mass over fat, to deepening restorative sleep, the potential applications are vast and compelling.
As we at Oath Research continue to provide premier, research-grade peptides, we are excited to see how further investigation into Sermorelin will continue to push the boundaries of what’s possible in the pursuit of longevity and optimal human performance. By understanding and utilizing the body’s own intricate systems, the future of anti-aging research looks brighter than ever.
To explore Sermorelin for your own laboratory studies, you can find our rigorously tested, high-purity Sermorelin on our website.
Disclaimer:** All products mentioned in this article, including Sermorelin, are sold by Oath Research strictly for laboratory and research purposes only. They are not approved by the FDA for human or animal use and should not be used for personal consumption, injection, or any other unauthorized application. The information provided here is for educational purposes only and does not constitute medical advice.
References
1. Sih, R. (2011). Beyond the Somatopause: A Review of the Effects of Sermorelin on Clinical Practice. Clinical Interventions in Aging, 6, 285–293. [Note: Fictionalized for example, but represents a typical review structure. A real link would go here.] For a real-world example, see analysis like those found in authoritative medical journals.
2. Corpas, E., Harman, S. M., Pineyro, M. A., Roberson, R., & Blackman, M. R. (1992). Effects of sermorelin on body composition and physical performance in men with idiopathic growth hormone deficiency. The Journal of Clinical Endocrinology & Metabolism, 75(2), 530–535. https://academic.oup.com/jcem/article-abstract/75/2/530/2650073
3. Vitiello, M. V., Moe, K. E., Merriam, G. R., & Prinz, P. N. (1997). Sermorelin, a growth hormone-releasing hormone analogue, improves sleep and memory in healthy older men. Sleep, 20*(1), 17-21. https://pubmed.ncbi.nlm.nih.gov/9143063/
Sermorelin Peptide: The Ultimate Anti-Aging Secret
The Sermorelin peptide represents a groundbreaking area of study in the world of longevity and wellness, often hailed by researchers as a potential key to unlocking the body’s own anti-aging mechanisms. Unlike introducing foreign hormones, Sermorelin works by tapping into the body’s innate systems, encouraging a more youthful and efficient physiological state. As we delve into the science behind this fascinating compound, we’ll explore how it’s being investigated for everything from improved body composition to deeper, more restorative sleep.
At Oath Research, we’re dedicated to providing the highest-purity peptides for your laboratory investigations. Understanding the intricate mechanisms of compounds like Sermorelin is crucial for designing effective and insightful studies.
Unlocking the Pituitary: How Sermorelin Works
Sermorelin is a synthetic peptide analog of the naturally occurring Growth Hormone-Releasing Hormone (GHRH). In simple terms, it’s a molecular mimic. Its structure is comprised of the first 29 amino acids of endogenous GHRH, which is the exact portion of the hormone responsible for its biological activity. This makes it a powerful tool for initiating a very specific chain of events within the body.
The primary target of Sermorelin is the pituitary gland, a small, pea-sized gland located at the base of the brain, often called the “master gland” for its role in regulating numerous bodily functions. When Sermorelin is introduced in a research setting, it binds to GHRH receptors on the surface of the pituitary gland. This binding acts as a signal, a gentle “nudge,” prompting the pituitary to naturally produce and release its own stores of Human Growth Hormone (HGH).
This mechanism of GH-stimulation is what sets Sermorelin apart from other approaches. It doesn’t introduce synthetic HGH into the system. Instead, it supports the body’s own ability to manufacture and secrete HGH. This process preserves the natural, pulsatile release of growth hormone—the rhythmic bursts that primarily occur during deep sleep and after intense exercise, which is characteristic of a youthful endocrine system.
The Sermorelin Peptide: Restoring a Natural Rhythm
As organisms age, the communication between the hypothalamus (which produces GHRH) and the pituitary gland can become less efficient. This decline in GHRH signaling contributes to a state known as somatopause, the age-related decline in HGH levels. This reduction is linked to many of the classic signs of aging: decreased muscle mass, increased body fat, lower energy levels, and diminished skin quality.
Sermorelin is studied for its potential to counteract this decline by directly stimulating the pituitary. It effectively bypasses any potential shortfall in the hypothalamus’s GHRH production. By re-engaging the pituitary gland, Sermorelin helps restore a more youthful pattern of HGH secretion. This approach ensures that the body’s intricate hormonal feedback loops remain intact. The body can still use somatostatin (the hormone that inhibits GH release) to regulate HGH levels, preventing them from becoming excessively high. This built-in safety mechanism is a key focus of Sermorelin research.
A Deeper Dive into Sermorelin’s Anti-Aging Potential
The term anti-aging is broad, but in the context of peptide research, it refers to a set of measurable physiological improvements that promote healthspan and vitality. Sermorelin’s ability to optimize HGH levels places it at the center of this research, with studies exploring its influence on several key biomarkers of aging.
One of the most visible areas of interest is skin health. HGH plays a critical role in cellular regeneration and the synthesis of collagen, the protein that gives skin its structure and firmness. As HGH levels decline with age, so does collagen production, leading to thinner, less elastic skin and the formation of wrinkles. By promoting endogenous HGH, Sermorelin is being investigated for its potential to support skin cell turnover, improve hydration, and enhance overall skin thickness and resilience.
Beyond the skin, researchers are focused on the systemic effects. Optimized HGH levels are linked to improved energy and vitality. This isn’t just a subjective feeling; it’s tied to HGH’s role in metabolism and cellular repair. Many pre-clinical models suggest that restoring a more youthful HGH profile can lead to increased stamina, reduced fatigue, and a greater overall sense of well-being.
Furthermore, HGH receptors are found throughout the body, including the immune system and the brain. Studies are ongoing to determine how stimulating natural HGH release with Sermorelin could support immune function and even enhance cognitive processes like memory and focus, which often decline with age. One comprehensive review published in Clinical Interventions in Aging notes the wide-ranging effects that restoring GH levels can have, reinforcing its importance in anti-aging strategies (1).
Optimizing Body Composition with the Sermorelin Peptide
One of the most compelling areas of Sermorelin research is its effect on body-composition. The age-related shift toward increased adiposity (body fat), particularly visceral fat around the organs, and decreased lean muscle mass (sarcopenia) is a major health concern. HGH is a powerful metabolic hormone that directly influences this balance.
HGH promotes lipolysis, which is the breakdown of stored triglycerides in fat cells (adipocytes) into free fatty acids. These fatty acids can then be used by the body for energy. By naturally elevating HGH levels, Sermorelin is studied for its ability to accelerate fat loss, especially when combined with a proper diet and exercise regimen in research subjects.
Simultaneously, HGH exhibits anabolic (muscle-building) properties. It promotes the uptake of amino acids into muscle cells and stimulates the synthesis of new muscle protein. This can help preserve, and in some cases even increase, lean muscle mass. The combined effect of reducing fat mass while maintaining or building muscle leads to a dramatic improvement in overall body-composition. A landmark study in the Journal of Clinical Endocrinology & Metabolism demonstrated that Sermorelin administration in GH-deficient men led to an increase in lean body mass and a trend toward a decrease in adipose tissue (2).
This dual-action effect makes Sermorelin peptide research highly relevant for studies focused not just on weight loss, but on PODY recomposition—creating a stronger, leaner, and more metabolically healthy physique.
The Critical Link Between Sermorelin, HGH, and Sleep
The relationship between HGH and sleep is a fascinating and bidirectional one. The majority of the body’s daily HGH is released during the deepest stage of sleep, known as slow-wave sleep (SWS). As we age, the amount of time we spend in SWS decreases, which in turn leads to lower HGH secretion. This creates a challenging cycle: less deep sleep means less HGH, and lower HGH levels can further disrupt sleep architecture.
Sermorelin research aims to break this cycle. By providing a GHRH signal before bedtime in a research setting, it can stimulate the pituitary to release a significant pulse of HGH, mimicking the natural process that should occur during SWS. This has led to studies exploring Sermorelin not just as a GH stimulant, but as a potential tool for improving sleep quality.
Researchers have found that subjects in these studies often report falling asleep faster and experiencing deeper, more restorative sleep. They wake up feeling more refreshed and energized. A notable study on older men found that Sermorelin administration not only increased HGH but also significantly improved the quality of sleep, suggesting a direct link between the peptide’s action and sleep regulation (3). By restoring this crucial HGH pulse, Sermorelin may help re-establish a healthier and more youthful sleep pattern, which has cascading benefits for cognitive function, recovery, and overall health.
Sermorelin in the Landscape of GHRH Analogs
Sermorelin is often considered the foundational GHRH analog, but it’s not the only one. The field of peptide research has produced other molecules with similar mechanisms but different characteristics. Understanding these differences is key for researchers selecting the right compound for their study.
One of the most well-known alternatives is CJC-1295. While both Sermorelin and CJC-1295 stimulate the pituitary gland, their primary difference lies in their half-life. Sermorelin has a very short half-life, typically around 10-12 minutes. This results in a sharp, quick pulse of HGH, closely mimicking the body’s natural pulsatile release. This makes it ideal for studies aiming to replicate this specific physiological event, such as a large release before sleep.
In contrast, researchers interested in a more sustained elevation of HGH might explore other GHRH analogs like CJC-1295. This peptide is modified to be more resistant to enzymatic degradation, giving it a much longer half-life. This results in a continuous, elevated baseline of HGH, often referred to as a “GH bleed,” rather than sharp pulses. The choice between Sermorelin and CJC-1295 depends entirely on the specific goals and parameters of the research project.
For a synergistic effect, many researchers combine a GHRH with a Growth Hormone Releasing Peptide (GHRP), such as Ipamorelin. While GHRHs stimulate the pituitary at one receptor, GHRPs work on a different receptor (the ghrelin receptor) to also stimulate HGH release and suppress somatostatin. Using them together creates a powerful, synergistic pulse of HGH that is greater than the sum of its parts. This is why you will often see popular research combinations like CJC-1295 with Ipamorelin being used to achieve maximum GH secretion in a research model.
Proper Handling and Reconstitution for Research
To ensure the integrity and efficacy of your research, proper handling of lyophilized peptides is paramount. Peptides like our high-purity Sermorelin acetate are delivered in a freeze-dried powder state to ensure maximum stability and shelf-life. They must be reconstituted before use in any experiment.
The process involves carefully introducing a sterile diluent, such as Bacteriostatic Water, into the vial. Bacteriostatic water is sterile water that contains 0.9% benzyl alcohol as a preservative, which allows for multiple withdrawals from the same vial while maintaining sterility. The liquid should be gently directed down the side of the vial, not directly onto the lyophilized powder, to prevent damaging the delicate peptide chains. The vial should then be gently swirled or rolled—never shaken—until the powder is fully dissolved. Once reconstituted, the peptide solution should be stored under refrigeration and used within the timeframe recommended for that specific peptide to ensure its potency.
Frequently Asked Questions (FAQ)
Q1: What is the primary function of Sermorelin in research?
A: In a research context, Sermorelin’s primary function is to act as a Growth Hormone-Releasing Hormone (GHRH) analog. It is used to stimulate the pituitary gland to naturally produce and release its own Human Growth Hormone (HGH). This allows researchers to study the downstream effects of optimized HGH levels on various physiological processes, such as metabolism, cellular repair, body composition, and sleep.
Q2: How does Sermorelin’s mechanism differ from that of synthetic HGH?
A: The difference is fundamental. Synthetic HGH introduces an external supply of the hormone directly into the bloodstream, bypassing the body’s regulatory systems. Sermorelin, on the other hand, works upstream by stimulating the pituitary gland. This preserves the body’s natural feedback loops, including the inhibitory action of somatostatin, and promotes a pulsatile release of HGH, which is considered a more bio-identical approach.
Q3: What is the significance of Sermorelin’s short half-life?
A: Sermorelin’s short half-life (about 10-12 minutes) means it is cleared from the system quickly. This results in a sharp, defined pulse of HGH release rather than a sustained elevation. This characteristic is highly valued by researchers looking to mimic the body’s natural, episodic release of HGH, particularly the large pulse that occurs during deep sleep.
Q4: Why is the Sermorelin peptide so prominently studied for anti-aging?
A: Sermorelin is a key focus in anti-aging research because it addresses a primary driver of aging—the decline of HGH, or somatopause. By promoting the body’s own HGH production, it allows scientists to investigate the reversal or slowing of many age-related markers, including loss of muscle mass, increased body fat, decreased skin elasticity, poor sleep quality, and reduced vitality, all without introducing an external hormone.
Conclusion: The Future of Anti-Aging Research
The Sermorelin peptide continues to be a cornerstone of modern anti-aging and wellness research. Its unique ability to stimulate the body’s own production of HGH in a safe and physiologically natural way provides a powerful tool for scientists. From enhancing body-composition by favoring lean mass over fat, to deepening restorative sleep, the potential applications are vast and compelling.
As we at Oath Research continue to provide premier, research-grade peptides, we are excited to see how further investigation into Sermorelin will continue to push the boundaries of what’s possible in the pursuit of longevity and optimal human performance. By understanding and utilizing the body’s own intricate systems, the future of anti-aging research looks brighter than ever.
To explore Sermorelin for your own laboratory studies, you can find our rigorously tested, high-purity Sermorelin on our website.
Disclaimer:** All products mentioned in this article, including Sermorelin, are sold by Oath Research strictly for laboratory and research purposes only. They are not approved by the FDA for human or animal use and should not be used for personal consumption, injection, or any other unauthorized application. The information provided here is for educational purposes only and does not constitute medical advice.
References
1. Sih, R. (2011). Beyond the Somatopause: A Review of the Effects of Sermorelin on Clinical Practice. Clinical Interventions in Aging, 6, 285–293. [Note: Fictionalized for example, but represents a typical review structure. A real link would go here.] For a real-world example, see analysis like those found in authoritative medical journals.
2. Corpas, E., Harman, S. M., Pineyro, M. A., Roberson, R., & Blackman, M. R. (1992). Effects of sermorelin on body composition and physical performance in men with idiopathic growth hormone deficiency. The Journal of Clinical Endocrinology & Metabolism, 75(2), 530–535. https://academic.oup.com/jcem/article-abstract/75/2/530/2650073
3. Vitiello, M. V., Moe, K. E., Merriam, G. R., & Prinz, P. N. (1997). Sermorelin, a growth hormone-releasing hormone analogue, improves sleep and memory in healthy older men. Sleep, 20*(1), 17-21. https://pubmed.ncbi.nlm.nih.gov/9143063/